Detalhe da pesquisa
1.
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.
Nature
; 608(7921): 174-180, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35732739
2.
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Proc Natl Acad Sci U S A
; 121(1): e2307086120, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38147543
3.
Systematic identification of biomarker-driven drug combinations to overcome resistance.
Nat Chem Biol
; 18(6): 615-624, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35332332
4.
TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease.
Mol Cell Proteomics
; 21(4): 100223, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35283288
5.
Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.
Circ Res
; 129(4): 458-470, 2021 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34176299
6.
Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism.
Proc Natl Acad Sci U S A
; 116(9): 3546-3555, 2019 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30755530
7.
Multimodal small-molecule screening for human prion protein binders.
J Biol Chem
; 295(39): 13516-13531, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32723867
8.
Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.
Proc Natl Acad Sci U S A
; 114(43): 11392-11397, 2017 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29073062
9.
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Nat Chem Biol
; 13(9): 943-950, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28671682
10.
Small-molecule WNK inhibition regulates cardiovascular and renal function.
Nat Chem Biol
; 12(11): 896-898, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27595330
11.
Identification of a new Corin atrial natriuretic peptide-converting enzyme substrate: Agouti-signaling protein (ASIP).
bioRxiv
; 2023 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37162877
12.
Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
Cardiovasc Res
; 118(13): 2833-2846, 2022 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34849650
13.
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.
Circ Genom Precis Med
; 14(5): e003399, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34592835
14.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem
; 64(15): 11148-11168, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34342224
15.
Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics.
Biochim Biophys Acta
; 1794(6): 961-7, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19236960
16.
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap.
Proteins
; 78(12): 2571-86, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20589640
17.
Development of a novel, sensitive cell-based corin assay.
Biochem Pharmacol
; 160: 62-70, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30553787
18.
Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
Nat Genet
; 49(9): 1392-1397, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28714974
19.
Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor.
Protein Sci
; 25(11): 2018-2027, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27534510
20.
Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).
ACS Med Chem Lett
; 5(12): 1308-12, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25516789